Hydrogen (H2) Studies
We have listed below some of the major studies.
As we speak a new Hydrogen Search engine is being developed
You can access it at hydrogenstudies.com and search for your individual condition or interest. I think you will find it very useful.

Brain & Neuro
- Bipolar and Schizophrenia and H2
- Neurological disorders and molecular hydrogen.
- Hydrogen helps with Parkinsons.
- Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial.
- Hydrogen water and Depression.
- Hydrogen water and Autism.
- Hydrogen Water: Autism and Ghrelin In Boys
- Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury.
- Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury.
- Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water.
- Electrochemically reduced water protects neural cells from oxidative damage.
- Hydrogen-rich saline improves memory function in a rat model Alzheimer’s disease.

Miscellaneous
- Clinical Studies and Research on Electrolyzed-Reduced Water
- Methods of Measuring Sterilization Effect of AEW for Cleaning Oral Cavities
- Hydrogen shown to regulate blood glucose levels.
- Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle
- Hydrogen water for antioxidants, glucose uptake, and insulin signaling.
- Targeting molecular hydrogen to mitochondria: Barriers and gateways
- Does H2 Alter Mitochondrial Bioenergetics via GHS-R1α Activation?

Heart

Human Studies
- Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.
- Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
- Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
- Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.
- Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro.
- Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome
- Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers.
- Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial.
- Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.

H2 As An Antioxidants
- Electrolyzed Reduced Water inhibits acute ethanol induced hangover
- Diabetes supplementation with hydrogen rich water improves lipid and glucose metabolism in T2DM and IGT
- Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein.
- Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
- Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.
- ONOOH (peroxynitrite) does not react with H2
- Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage.

Water Facts/Studies
- Evaluation of Electrolytically-Generated Hypochlorous Acid (‘Electrolyzed Water’) for Sanitation of Meat and Meat-Contact Surfaces
- Efficacy of Electrolyzed Oxidizing Water for Ecoli, Salmonella enteritidis, and Listeria monocytogenes.
- 24,500 Chemicals Found in Top 18 Brands of Bottled Water
- Drugs in the Drinking Water

Inflammation & Pain
- How much water should you drink daily?
- Electrolyzed H2O Protects DNA Study
- Rheumatoid Arthritis
- Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress.
- Eumelanin-driven production of molecular hydrogen: A novel element of skin defense?
- Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
- Effect of electrolyzed water on wound healing.
- Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats.

Cancer
- Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid
- Hyperbaric hydrogen therapy: a possible treatment for cancer
- Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.
- Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells
- Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer.
- Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.
- Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione.

Colon & Detox
- Selective stimulation of the growth of anaerobic microflora in the human intestinal tract with electrolyzed reducing (hydrogen) water.
- How diet affects the gut.
- Anti-inflammatory properties of H2 investigation on parasite-induced liver inflammation.
- Non-gut microbiota as a source of bioactive hydrogen
- Protective effects of hydrogen-rich saline on ulcerative colitis.
- Hydrogen May Be Used as a Treatment for Stress-Induced Gastric Ulceration.
- Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.
- Potential ghrelin-mediated benefits and risks of hydrogen water
- Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water.
- Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.

Exercise & Fitness
- Pilot Study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes
- Hydrogen helps to improve Obesity
- Hydrogen effects on collagen and wrinkles.
- Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives
- Is melanin a source of bioactive molecular hydrogen?
- Should hydrogen therapy be included in a musculoskeletal medicine routine?
- Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes?
- Hydrogen-Rich Water Affected Blood pH in Physically Active Men
- Effectiveness of Oral and Topical Hydrogen for Sports-Related Soft Tissue Injuries
- Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women
- Molecular hydrogen in sports medicine: new therapeutic perspectives.
- Hydrogen-rich water affected blood alkalinity in physically active men.

Eyes & Ears
- Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats.
- Cataract Hypothesis Hydrogen-Rich Saline as an Innovative Therapy For Cataract
- Hydrogen protects auditory hair cells from free radicals
- Capabilities of hydrogen Molecules for use in the prevention and treatment in noise induced hearing loss
- Hydrogen-rich saline ameliorates the retina against light-induced damage in rats
- Hydrogen saline prevents selenite-induced cataract in rats.

Skin
- Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.
- Eumelanin-driven production of molecular hydrogen: A novel element of skin defense?